Showing posts with label sleep restriction. Show all posts
Showing posts with label sleep restriction. Show all posts

Tuesday, August 9, 2016

The Benefits of Sleep

           “If you die in your dream then you’ll die in real life too!” This was a belief I often heard whispered with reverence on the playground in my younger years. Older kids would nod sagely, as if they had a friend who had died in such a manner. For as kids, sleep was special and mysterious- and we all wanted more of it. But as we grow older, the specialness of sleep seems to fade as we focus more on getting at least the minimal amount of sleep needed for functioning. According to the Center for Disease Control, one in three Americans is sleep deprived, usually chronically. And this lack of sleep, however, impacts the important role sleep has in maintaining our mental health. Without adequate rest, we are prone to act in irrational and non-adaptive ways (such as binging on sweets or becoming easily upset).
        Although much research has focused on the detrimental effects of sleep deprivation, further research is need to understand what happens during this portion of non-consciousness. As far as we can tell, every living thing from trees to flies has some form of sleep or quiescence (quiet resting) during which it recovers from previous activity. In smaller, simpler organisms, this quiescence might only include clearing cellular debris but in more complicated organisms this sleep period is also important for changes in the brain. In humans, sleep is a privileged period of time when the brain doesn’t have to take in external information. Instead the mind prioritizes shuffling and re-organizing information learned during the day. We call this process of organizing and solidifying information memory consolidation. Most scientists agree that this process is always going on, but is especially prevalent during sleep. Memory consolidation is one reason why consistent sleep is so important for our daily lives.
        When we are sleep deprived, we restrict our brain’s ability to organize and prepare for the next day. This means that we are more likely to be forgetful, impulsive, and moody. College students who assume that they will do better in the exam by pulling an all-nighter are actually making it more difficult for themselves to succeed. Sleep deprivation is especially damaging because the part of our brain necessary for forming memories, the hippocampus, is particularly sensitive to sleep deprivation. It’s almost like a switch where at a certain point you are unable to learn and retain almost any information you are studying late into the night.
In addition to impairing memory, not getting enough sleep can also lead to motor control problems. If you’ve ever noticed that you seem to be less coordinated after staying up all night (or not getting enough sleep for a prolonged period of time), the loss of sleep is probably to blame. Coordinated motor control, especially for fine motor control is actually a complicated mental ability. So when you are sleep deprived, you aren’t able to respond as quickly or accurately to your surroundings. This problem has serious implications for professional truckers or others who drive long distances. In America, more than 1550 people are now killed by sleep-deprived automotive drivers.
The above mentioned problems are only a few of the consequences of sleep deprivation on the brain. In recent years there has been an escalating interest in the cognitive effects of sleep and why sleep is so important for a huge variety of mental abilities. But despite the accumulating evidence of sleep’s importance, Americans still tend to habitually stay up late and rise too early- putting us at a constant disadvantage. Thankfully, there are a few simple tricks that have been shown to help the chronically sleep deprived get some rest. First, going to sleep and waking at a consistent time each day helps us set our internal clock so it’s easier to fall asleep and we get quality rest. Another simple trick is treating your bedroom as a place reserved for sleep. Avoid watching TV or playing video games in bed as this creates a mental association between your bed and these activities instead of sleep. These tricks, along with avoiding caffeine in the evening, can greatly improve your ability to get restful sleep.
So maybe the schoolyard wisdom about dying in your dreams doesn’t hold up to modern science. In fact, the relationship seems to go the other way: a prolonged lack of sleep can actually cause death. But schoolyard children are right to think of sleep with awe and wonder.
There is some truth in the thought that sleep is a special period of time important to our health and well-being. We should retain some of that awe and wonder from our childhood years and realize how special sleep is.


Footnotes:
I would like to say a special word of thanks to ComSciCon16 for helping me craft this piece. It's a wonderful convention/program that has provided me with lots of feedback, as well as helping me make connections with other interested science communicators.  

Thursday, June 6, 2013

Chronic sleep restriction affects behavioral and ERP correlates of psychomotor vigilance - AKA My First Poster

I suppose this entry is technically late. Tuesday represented my big debut into the fascinating world of sleep research with my first-ever poster session. Sure, I was able to assist in a presentation in January at an aging conference but this was the first work that I've ever presented solo. It was both terrifying and exhilarating. I probably spent the first 15 minutes alternating between terror that someone would ask a question and worry that no one would ask me about my research. But, unsurprisingly, the session went well with polite, friendly people asking a few questions and some even complementing me on my research. And now that I've run through my little spiel in an academic setting, I feel comfortable in sharing it here on the internet. Keep in mind, this isn't an exact replica of my academic-version of the presentation because I know how daunting such technical jargon can be.
The Constellation in Baltimore's Inner Harbpr

My lab was interested in how chronic sleep restriction (a lessening, but not total deprivation of sleep) affects sustained attention, both as a behavioral measure and through recordings of EEG*. Past research has shown that the PVT (psychomotor vigilance task) is an accurate measure of sustained attention. For an abbreviated, modified version of the task, click here. But essentially, participants were asked to watch the screen and hit the spacebar whenever they saw a stopwatch appear on the screen.

Our experimental design began with recruiting 24 undergraduate students with no neurological or psychological problems (including sleep disorders). We had them come into the lab where we recorded resting state EEG (which is sort of a baseline cortical activity) and recorded EEG while they performed the PVT. We then gave them actigraphs (wristwatches that record movement and thereby objective measures of sleep-wake cycles) and asked them to fill out a sleep log entry each day. There were approximately 6 weeks between each of the 3 EEG sessions so we got a span of the full semester.

Based on this data, we found that average daily sleep decreased between session 1 and sessions 2 & 3 (from around 7hrs to 6.5hrs) and this negatively predicted reaction times on the PVT. In other words, sleep went down and time it took to react went up.
My poster

On the EEG side, we found the amplitude of the P3 component significantly decreased from session 1 to sessions 2 & 3. P3 is a change in voltage which has been linked to decision-making in past research. We also found that alpha reactivity amplitude decreased between session 1 and sessions 2 & 3. This component is a little difficult to explain in layman's terms, but essentially a lowered amplitude in alpha reactivity has been linked to dementia, traumatic brain injury, and aging.

The changes in P3 amplitude and alpha reactivity each negatively predicted reaction times both across and within-subjects. What makes this incredible to me is that we saw such clear effects from only avery small change in average daily sleep. We plan to look from here at more specific measures of sleep such as circadian rhythms and sleep latency.

So, that's more or less what I got to present at the conference. It was pretty incredible to talk to so many experts in the field and I look forward to attending next year (hopefully!). For now, I've just settled into my room at Albert Einstein College of Medicine and have started to learn a little about what I'll be doing this summer. More to come on the New York experience next time!

*EEG or electroencephalography is a technique used to record electric potentials created by brain activity and recorded through the scalp. EEG is known for its high temporal (time-based) resolution, but low spatial (location-based) resolution. This makes it good for looking at timing in activation in the brain, but we cannot always locate the origin of the activation.
After a successful, if exhausting, first poster session.

Monday, June 3, 2013

Sleep Conference 2013- The Stuff of Dreams

I can't believe I'm here in Baltimore, MD at the annual Sleep Conference! This is my first real academic conference and already I'm exhausted and delighted. There are talks and posters over an entire spectrum of sleep-related fields (cognition, disease, metabolic rates, etc.)

While I've had a full day of presentations, I think my favorite topic of the day has been sleep, circadian rhythms, and metabolism. I suppose it could be because this is the issue most relevant to my current lifestyle. As an undergraduate student, twice a year the dreaded finals swing around and you find people living in the library and barely sleeping. These same students, afraid to waste precious procrastinating studying time, bring boxes of goldfish and coolers filled with red bull to sustain them. Personally, I try to avoid this behavior but I'm not always successful. And it's usually on nights when I'm scarfing down a whole box of cookies that I wonder, 'how the heck can I be so hungry when I've been sitting perfectly still for the last 8 hours?'

Well I'm not saying that the Sleep Conference is my personal answer to this question, but there has been quite a bit of recent research linking sleep deprivation with increased hunger, caloric consumption, and (in the end) weight gain. What I found most interesting was that one study (which I believe came out of this link) showed that sleep deprived participants did consume more calories, but statistically consumed less calories per waking hour than non-sleep restricted participants. This indicates to me that caloric intake isn't the whole story, and perhaps metabolic rates are shifted because of the lack of sleep so that the calories consumed are not efficiently put to use.

Mind you, this is just my take on a particular presentation and I suggest checking out original sources such as this to get the full story. Please feel free to chime in on the comments below as well!